Peer-reviewed veterinary case report
Gain of 'FAOnction', Loss of Fibrosis.
- Journal:
- Trends in endocrinology and metabolism: TEM
- Year:
- 2021
- Authors:
- Nicholson, Rebekah J et al.
- Affiliation:
- Department of Nutrition and Integrative Physiology · United States
Abstract
Recent research by Miguel et al. and Dhillon et al. reveals associations between impaired lipid metabolism and kidney fibrosis. Kidney tubule fatty acid oxidation (FAO) gain-of-function in mouse models of kidney disease stimulated cellular respiration, mitochondrial dynamics, and tubular epithelial cell (TEC) differentiation, while upregulation of FAO in kidney tubules provided protection from kidney fibrosis and functional decline.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33773899/