Peer-reviewed veterinary case report
Galanin enhances and a galanin antagonist attenuates depression-like behaviour in the rat.
- Journal:
- European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
- Year:
- 2007
- Authors:
- Kuteeva, Eugenia et al.
- Affiliation:
- Department of Neuroscience
- Species:
- rodent
Abstract
The effect of intracerebroventricular infusion of galanin and/or the galanin antagonist M35 was studied in the forced swim test. Animals were pre-exposed to water for 15 min 24 h prior to test. Immobility and climbing were assessed during the second, 5 min exposure to water. Rats receiving a single infusion of galanin (3 nmol) displayed a significant increase of immobility. This effect was blocked by co-administration of M35 (1 nmol). M35 alone (1 nmol) produced a significant decrease of immobility. The results further support the hypothesis that galanin may play a role in mood disorders, and that galanin antagonists may represent new candidates for antidepressant treatment.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16624535/