Peer-reviewed veterinary case report
Dog with IgA multiple myeloma showing two M-component gammopathy
By Kato, H et al.·Published in Veterinary immunology and immunopathology·1995·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Gammopathy with two M-components in a dog with IgA-type multiple myeloma.
- Species:
- dog
Plain-English summary
A 12-year-old neutered male mixed-breed dog was brought to the vet because he had chronic diarrhea. Tests showed that he had a condition called gammopathy, which means he had abnormal proteins in his blood, specifically two types of IgA antibodies. This buildup of proteins made his blood thicker than normal, leading to serious health issues. Unfortunately, this condition was severe and indicated that the dog was in the final stages of illness.
People also search for: dog chronic diarrhea causes · mixed-breed dog gammopathy treatment · IgA myeloma in dogs
Abstract
A 12-year neutered male mixed-breed dog was referred to hospital for evaluation of chronic diarrhea. Cellulose acetate electrophoresis of its serum revealed two monoclonal peaks in the gamma-globulin fraction. On immunoelectrophoretic analysis, the two monoclonal peaks in the gamma-globulin region were strongly precipitated with anti-dog IgA serum. On sodium dodecyl sulfate-polyacrylamide gel electrophoretic analysis, the fractions corresponding to these two peaks were shown to be dimer and trimer or tetramer of immunoglobulin consisting of heavy and light chains. These results indicated that the studied dog had gammopathy with two M-components with dimer and trimer or tetramer of IgA. Accumulations of large amounts of these immunoglobulins with very high molecular weight in the serum were concluded to induce the hyperviscosity syndrome in this dog in the terminal stage.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8588338/