Peer-reviewed veterinary case report
Cat with splenic mass and anemia caused by Gamna-Gandy bodies
By Ryseff, Julia K et al.·Published in Veterinary clinical pathology·2014·Department of Microbiology, United States·View original on PubMed →
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Original publication title: Gamna-Gandy bodies: a case of mistaken identity in the spleen of a cat.
- Species:
- cat
Plain-English summary
A 4-year-old female spayed Domestic Shorthair cat was brought to the vet after showing signs of lethargy, not eating, and vomiting for two days. Tests revealed she had severe anemia and a large mass in her spleen. A closer examination of the mass suggested it might be a type of cancer called histiocytic sarcoma, but it turned out to be Gamna-Gandy bodies, which are related to bleeding in the tumor. The cat's condition was serious, and treatment options would depend on the vet's recommendations based on the final diagnosis.
People also search for: cat vomiting and lethargy · cat spleen mass treatment · histiocytic sarcoma in cats
Abstract
A 4-year-old, female spayed Domestic Shorthair cat was presented for a 2-day history of lethargy, anorexia, and vomiting. Diagnostic assessments revealed a severe, regenerative anemia and the presence of a solitary, 3 × 4 cm splenic mass. Cytologic examination of fine-needle aspirates of the splenic mass showed sheets of pleomorphic histiocytic cells with numerous intracellular and extracellular, negatively staining to deeply basophilic, branching structures. These structures were typically of thin uniform thickness with random angled branching that formed geometrical shapes and fragments, occasionally with sharpened ends and a crystalline appearance. Septal-like divisions were irregularly spaced along some of the linear branches. The cytology was interpreted as a probable histiocytic inflammatory response to the unidentified foreign material with histiocytic sarcoma as a differential diagnosis. Histopathologic evaluation of the splenic mass resulted in a diagnosis of histiocytic sarcoma. The branching material stained positively for both iron and calcium, indicating that the material was compatible with Gamna-Gandy bodies present secondary to tumor-associated hemorrhage and the formation of calcium-iron complexes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24446697/