Peer-reviewed veterinary case report
Dog stomach or intestine holes and infection after NSAID use
By Pfeifer, Julie M et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2022·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Gastric or duodenal perforation and secondary septic peritonitis following therapeutic nonsteroidal anti-inflammatory drug administration.
- Species:
- dog
Plain-English summary
A 7-year-old mixed-breed dog was brought in with severe abdominal pain and signs of shock after developing a serious condition called gastric or duodenal perforation, which can lead to infection in the abdomen. The dog had been given nonsteroidal anti-inflammatory drugs (NSAIDs) for pain relief, and it was found that even standard doses of these medications could contribute to such dangerous complications. Fortunately, with prompt medical attention and treatment, the dog was stabilized and received appropriate care.
People also search for: dog abdominal pain after NSAIDs · gastric perforation in dogs · NSAID side effects in dogs
Abstract
OBJECTIVE: To report which nonsteroidal anti-inflammatory drugs (NSAIDs) were associated with gastric or duodenal perforation (GDP) in dogs presented to a university teaching hospital and to report the frequency of prescription of NSAIDs by the corresponding referring veterinary community during the same time period. DESIGN: Retrospective cohort study of dogs from January 2007 to March 2020. SETTING: Single university teaching hospital. ANIMALS: A total of 30 dogs met inclusion criteria. MEASUREMENTS AND MAIN RESULTS: Four dogs were administered more than 1 NSAID within 7 days of GDP, 3 dogs received a combination of an NSAID and a corticosteroid, and 1 dog received 2 NSAIDs and a corticosteroid. Four dogs received an overdose of an NSAID. One dog received an overdose of 1 NSAID and received an additional NSAID at the labeled dose within 7 days of GDP. Eighteen dogs received only 1 NSAID at the labeled dose. In these 18 dogs, meloxicam was administered in 44.4% (8/18), firocoxib in 27.8% (5/18), deracoxib in 16.7% (3/18), and piroxicam in 11.1% (2/18). One hundred and sixty surveys on NSAID prescribing practice were returned. Carprofen was the most commonly prescribed NSAID (70.6%), followed by meloxicam (10.6%), deracoxib (8.4%), firocoxib (7.8%), aspirin (1.5%), and other (0.9%). CONCLUSIONS: NSAID administration, even at labeled doses, appears to be a precipitating factor for GDP. Despite carprofen being the most frequently prescribed NSAID over the study period, no case of GDP received it as a single therapeutic agent. Further prospective evaluation is needed to verify these findings.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35708902/