Peer-reviewed veterinary case report
Gelatin sealing sheets stop bleeding and prevent scars in dog artery
By Hu, Yinghao et al.·Published in Bio-medical materials and engineering·2015·Department of Thoracic and Cardiovascular Surgery, Japan·View original on PubMed →
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Original publication title: Gelatin sealing sheet for arterial hemostasis and anti-adhesion in vascular surgery: a dog model study.
- Species:
- dog
Plain-English summary
A group of dogs underwent surgery where small holes were made in their femoral arteries to test a new gelatin sealing sheet designed to stop bleeding. Both the gelatin and a standard fibrin glue were used to seal the holes, and both were effective in stopping the bleeding. However, the gelatin sheet resulted in significantly less inflammation and fewer adhesions at the surgery site after four weeks compared to the fibrin glue. This suggests that the gelatin sealing sheet could be a safer and more effective option for managing bleeding during surgery in dogs.
People also search for: dog surgery bleeding control · gelatin sealing sheet for dogs · fibrin glue vs gelatin in surgery
Abstract
BACKGROUND: The bilayer gelatin sealing sheet was developed as a safe, effective, easy-to-handle and low-cost hemostatic agent. OBJECTIVE: To examine the feasibility of gelatin sealing sheets using a canine arterial hemorrhage model. METHODS: In vivo degradation of gelatin sealing sheets was examined by implanting subcutaneously in rats. For the hemostatic and anti-adhesion efficacy investigations, femoral arteries of dogs were pricked with syringe needle to make a small hole and a gelatin (i.e. experimental group) or fibrin glue sealing sheet (i.e. control group) was applied on the hole to stop bleeding (n=8). After discontinuation of the bleeding, the skin incisions were closed and re-examined 4 weeks postoperatively. RESULTS: From the degradation study, 4 h thermally treated gelatin sheet which degraded within 3 weeks in vivo was chosen for the further hemostatic study. In all cases of gelatin and fibrin glue sealing sheets, bleeding from the needle hole on canine femoral arteries was effectively stopped. Postoperative adhesions and inflammation at the site in the experimental group were significantly less than those in the control group (P<0.01 for adhesion scores). CONCLUSIONS: The gelatin sealing sheet was found to be as effective as the fibrin glue sealing sheet as a surgical hemostatic agent, and more effective in preventing postoperative adhesions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25813954/