Peer-reviewed veterinary case report
Leucine-rich alpha-2 glycoprotein gene in dachshund colorectal polyps
By Ohta, Hiroshi et al.·Published in The Journal of veterinary medical science·2020·Graduate School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Gene expression of leucine-rich alpha-2 glycoprotein in the polypoid lesion of inflammatory colorectal polyps in miniature dachshunds.
Plain-English summary
A group of miniature dachshunds with inflammatory colorectal polyps (ICRPs) showed increased levels of a specific gene linked to inflammation. These polyps can be a sign of a breed-specific inflammatory bowel disease (IBD). Researchers found that the gene expression of leucine-rich alpha-2 glycoprotein (LRG) was significantly higher in the polyp samples compared to normal tissue, suggesting it could be a useful marker for this condition. Understanding these changes may help veterinarians better diagnose and treat ICRPs in dachshunds.
People also search for: miniature dachshund inflammatory bowel disease · dog colorectal polyps symptoms · dachshund IBD treatment
Abstract
Inflammatory colorectal polyps (ICRPs) in miniature dachshunds (MDs) are speculated to be a breed-specific inflammatory bowel disease (IBD). Leucine-rich alpha-2 glycoprotein (LRG) has been identified as a novel biomarker of human IBD. The aim of this study was to examine LRG gene expression in the polypoid lesions of ICRPs. Polypoid lesion specimens were collected from 24 MDs with ICRPs. Nonpolypoid colonic mucosa was collected from 18 MDs with ICRPs and 10 controls. The gene expression of LRG, interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and IL-22 was examined. The expression of LRG gene was significantly increased in the polypoid lesions of ICRPs and correlated with that of the four cytokines. In conclusion, the LRG gene was expressed within the polypoid lesions of ICRPs and might be associated with local cytokine expression.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32759576/