Peer-reviewed veterinary case report
Cytokine gene changes in duodenal tissue of dogs with inflammatory
By Schmitz, Silke et al.·Published in Veterinary immunology and immunopathology·2012·Royal Veterinary College, United Kingdom·View original on PubMed →
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Original publication title: Gene expression of selected signature cytokines of T cell subsets in duodenal tissues of dogs with and without inflammatory bowel disease.
- Species:
- dog
Plain-English summary
Inflammatory bowel disease (IBD) is a common reason for chronic diarrhea in dogs. This study looked at the levels of certain proteins called cytokines, which are important for immune responses, in the intestines of 18 German shepherds and 33 other breeds with IBD, compared to 15 healthy dogs. The researchers found that a specific cytokine, IL-17A, was lower in the dogs with IBD, but other cytokines did not show significant differences between the groups. Overall, the study did not find strong evidence that certain immune cells are involved in canine IBD, suggesting that more research is needed to understand the condition better.
Abstract
Inflammatory bowel disease (IBD) is a common cause of chronic diarrhoea in dogs. In people, specific cytokine patterns attributed to T cell subsets, especially T helper cell [Th]1, Th17 and regulatory T(reg) cells have emerged in IBD. In contrast, no specific involvement of a distinct T cell subset has been described so far in canine IBD. Thus, the aim of the present study was to assess gene expression of signature cytokines in duodenal tissues from 18 German shepherd dogs with IBD (group 1), 33 dogs of other breeds with IBD (group 2) and 15 control dogs (group 3). Relative quantification of IL-17A, IL-22, IL-10, IFNy and TGFβ was performed. Expression of IL-17A was significantly lower in groups 1 and 2 compared to group 3 (p=0.014), but no difference in the expression of IL-22 (p=0.839), IFNγ (p=0.359), IL-10 (p=0.085) or TGFβ (p=0.551) across groups was detected. Thus, no clear evidence for the involvement of Th-17 signature cytokines in canine IBD at the mRNA level could be shown. The contribution of specific T cell subsets to the pathogenesis of canine IBD warrants further investigation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22333286/