Peer-reviewed veterinary case report
Generation of osteoporosis in immune-compromised mice for stem cell therapy.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2014
- Authors:
- Aggarwal, Reeva et al.
- Affiliation:
- The Dorothy M. Davis Heart and Lung Research Institute · United States
- Species:
- rodent
Abstract
To evaluate therapeutic efficacy and to investigate involved molecular mechanisms of cell-based therapy in osteoporosis, the generation of a clinically relevant model is critically important. Herein, we describe detailed methods in generation of an immune-deficient osteoporotic murine model, and application of human umbilical cord blood-derived stem cells to assess their therapeutic efficacy.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25173385/