Peer-reviewed veterinary case report
Genetic differences and symptoms of two cat calicivirus strains
By Lu, Chengyun et al.·Published in Veterinary research communications·2023·College of Veterinary Medicine, China·View original on PubMed →
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Original publication title: Genetic and pathogenicity analysis for the two FCV strains isolated from Eastern China.
- Species:
- cat
Plain-English summary
Two cats were experimentally infected with different strains of feline calicivirus (FCV) from Eastern China. One cat showed symptoms like sneezing, fever, and eye irritation, but thankfully recovered within 30 days. The other cat had no symptoms and cleared the virus in just 16 days. This suggests that while both strains were less severe, the strain causing symptoms might have specific mutations linked to how sick a cat can get.
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Abstract
In this study, the diversity and regularity of two new feline calicivirus (FCV) isolates, QD-7 and QD-164, were investigated. The genomes of these new strains were compared with 39 strains from the NCBI database including isolates from China, United States, Germany, South Korea, the United Kingdom and Japan. The nucleotide sequence identities ranged from 75-88%, indicating a high degree of variability. These variations were not related to distributions of the virus by time of isolation and geographical location. Cats that were experimentally infected with the new isolate QD-164 showed typical clinical symptoms of sneezing, fever and conjunctivitis and all recovered within 30 days. In contrast, QD-7 infections were asymptomatic and the virus was cleared within 16 days. These results indicate that QD-7 and QD-164 were naturally attenuated strains. NNS mutations characteristic of highly virulent strains at positions 441-443 were absent in QD-7 while QD-164 possessed an N at position 442. This indicated that mutations in regions 441-443 may be linked to disease severity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37454000/