Peer-reviewed veterinary case report
Genetic and pharmacological suppression of polyglutamine-dependent neuronal dysfunction in Caenorhabditis elegans.
- Journal:
- Journal of molecular neuroscience : MN
- Year:
- 2004
- Authors:
- Parker, J Alex et al.
- Affiliation:
- Laboratory of Genomic Biology · France
Abstract
The identification of disease genes for several neurodegenerative illnesses has allowed for the development of disease models in experimental organisms. We discuss our approach to studying Huntington's disease, the best characterized of the polyglutamine (polyQ) expansion disorders. We have developed a system in Caenorhabditis elegans to study the effects of (polyQ)-dependent neuronal dysfunction at the resolution of two neurons in screening for genetic and pharmacological suppression. Our data suggest that C. elegans might be instructive in searching for targets and active compounds against polyglutamine neuronal toxicity.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15126693/