Peer-reviewed veterinary case report
Cats in Italy with urinary infections carrying resistant E coli ST131
By Nebbia, Patrizia et al.·Published in Journal of feline medicine and surgery·2014·University of Turin, Italy·View original on PubMed →
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Original publication title: Genetic and phenotypic characterisation of Escherichia coli producing cefotaximase-type extended-spectrum β-lactamases: first evidence of the ST131 clone in cats with urinary infections in Italy.
- Species:
- cat
Plain-English summary
A group of cats in Italy with urinary tract infections was found to have a specific type of E. coli bacteria that produces a resistance enzyme, making treatment more difficult. Out of 138 urine samples tested, 7 had this resistant strain, which is known as CTX-M. The study identified various genetic traits of these bacteria, including one strain that is particularly concerning due to its ability to resist multiple antibiotics. This finding highlights the importance of careful diagnosis and antibiotic use in pets to prevent the spread of these resistant infections.
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Abstract
The incidence of cefotaximase (CTX-M)-type extended-spectrum β-lactamase (ESBL)-producing Escherichia coli has increased dramatically in humans and animals since the middle of the last century. E coli that produce CTX-M β-lactamase represent a major cause of urinary tract infections, and pose a significant therapeutic challenge to both human and veterinary medicine. As data on uropathogenic CTX-M-producing strains in cats are limited, the aim of this study was to describe the genetic character and antibiotic resistance phenotypes of CTX-M-producing E coli isolated from cats with cystitis. Seven of 15 E coli bacteria isolated from 138 urine samples had the CTX-M gene and were therefore included in this study. These isolates were screened by polymerase chain reaction for the presence of 14 extra-intestinal virulence factors, class 1 and class 2 integrons, and to identify their phylogenetic groups. Multi-locus sequence typing (MLST) of the strains and susceptibility testing (disc diffusion method) were also performed. Virulence factor iutA was the most frequent determinant identified (86.7%), and the majority of CTX-M-producing strains (n = 5) carried class 1 integrons. MLST allowed us to discriminate four known sequence types (ST131, ST555, ST602, ST155) and three novel sequence types (ST3847, ST3848, ST4181). To the best of our knowledge, this is the first study to report uropathogenic CTX-M-producing E coli ST131 in cats in Italy. Accurate diagnostics and prudent use of antimicrobials are recommended to avoid the spread of multidrug-resistant pathogens in veterinary medicine and to prevent their transmission to humans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24621854/