Peer-reviewed veterinary case report
Canine bufavirus genetic diversity in dogs with diarrhea in China
By Ji, Jun et al.·Published in Veterinary journal (London, England : 1997)·2024·Nanyang Normal University, China·View original on PubMed →
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Original publication title: Genetic and recombination heterogeneity of canine bufaviruses detected in diarrheal dogs in China.
- Species:
- dog
Plain-English summary
A group of dogs in China with diarrhea was tested for a virus called canine bufavirus (CBuV), and 14 of the 622 dogs had the virus. Some of these dogs were also infected with other viruses that cause diarrhea, like parvovirus and coronavirus. The researchers found that the CBuV strains had some genetic similarities to strains from Italy and Hungary, indicating that they may have evolved through recombination. This study helps improve our understanding of CBuV and could assist in developing vaccines for dogs in the future.
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Abstract
Bufavirus (BuV) was first identified in feces from children with acute diarrhea, and a genetically related Canine bufavirus (CBuV) was first reported in Italy in 2018. In this study, through the investigation of CBuV in 622 anal swabs from dogs with diarrhea symptoms collected from various provinces in northern, central and eastern China during 2018-2022, 14 samples were detected to be positive. And 5 samples were from dogs co-infected with other canine diarrhea related viruses, which consist of CPV-2, CDV and CCoV. The complete genome sequences (4219 nt) of the fourteen strains were amplified and sequenced. Through comparative analysis with 51 reference BuV strains, six strains might recombinate from the CBuV strains (HUN/2012/22, CaBuV/9AS/2005/ITA and CaBuV/35/2016/ITA) in Hungary and Italy as the parents, and two genetic recombination events from various parents were predicted to occur on the BUV-422 strain. Combined analyzing the phylogenetic tree and sequence alignment, it was found that these CBuVs are highly conserved in the nonstructural protein NS1, but indeed various amino acid mutation sites in the capsid protein VP2, and even some amino acid sites coincide with putative protein plastic regions and potential epitopes. The BUV-422 and BUV-512 strains show sequential mutation sites identical to the divergent strains of CaBuV/9AS/2005/ITA and CaBuV/35/2016/ITA. This study would enrich the molecular data of CBuV in China and provide essential reference for the epidemiological research and vaccine development of CBuV in the future.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38964602/