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Peer-reviewed veterinary case report

Genetic animal models of preconditioning.

Journal:
Translational stroke research
Year:
2013
Authors:
Azad, Priti & Haddad, Gabriel G
Affiliation:
Department of Pediatrics (Section of Respiratory Medicine) · United States

Abstract

The preconditioning phenomena have been well established in heart as well as brain. In this review, we detail some of the original studies on preconditioning as well as studies from our lab using rodents and a genetic model system (fruit fly). We have used Drosophila in our lab to solve some of the questions related to tolerance or susceptibility to hypoxia. We believe that these pro-survival strategies and genetic pathways help us understand some of the preconditioning mechanisms that protect the brain from ischemia or ischemia.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/23565128/