Peer-reviewed veterinary case report
Genetic association between NOD2 polymorphism and infection status by Mycobacterium avium ssp. paratuberculosis in German Holstein cattle.
- Journal:
- Animal genetics
- Year:
- 2014
- Authors:
- Küpper, J D et al.
- Affiliation:
- Institut fü · Germany
Abstract
The aim of the study was the analysis of the nucleotide-binding oligomerization domain containing 2 (NOD2, formerly CARD15) as a candidate gene for Mycobacterium avium ssp. paratuberculosis infection in cattle. Eleven SNPs in the NOD2 gene were identified, and finally, four SNPs were included in a case-control study using 324 German Holstein cows tested for paratuberculosis using fecal culture and ELISA. The SNP (GenBank) AY518738S04:g.521G>A in exon 4 showed a significant association between the fecal culture status of the animals and NOD2 allele variants. The other three SNPs showed no associations in German Holstein cows.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24320212/