Peer-reviewed veterinary case report
Genetic determinant of intrinsic quinolone resistance in Fusobacterium canifelinum.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2005
- Authors:
- Conrads, Georg et al.
- Affiliation:
- Division of Oral Microbiology and Immunology University Hospital · Germany
Abstract
Fourteen fluoroquinolone-resistant fusobacterial strains, originating from cats or dogs, were characterized by sequencing of the 16S-23S and 16S rRNA genes and DNA-DNA hybridization and were described as a new species, Fusobacterium canifelinum. All of the strains are intrinsically resistant (MIC, >4 g/ml) to levofloxacin and other fluoroquinolones. Compared to the quinolone resistance-determining region (gyrA) of the susceptible relative F. nucleatum, we found that Ser79 was replaced with leucine and Gly83 was replaced with arginine.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15616329/