Peer-reviewed veterinary case report
New genetic markers linked to hip dysplasia and arthritis in dogs
By Mikkola, Lea et al.·Published in BMC Genomics·2019·View original on Crossref →
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Original publication title: Genetic dissection of canine hip dysplasia phenotypes and osteoarthritis reveals three novel loci
- Species:
- dog
Plain-English summary
A group of German shepherds with hip dysplasia and osteoarthritis was studied to understand the genetic factors behind these conditions. The dogs were evaluated using X-rays to determine the severity of their hip dysplasia, which can cause pain and mobility issues. Researchers identified three significant genetic locations that may influence the development of hip joint problems. This research could help in developing better treatments and management strategies for dogs suffering from these painful conditions.
People also search for: German shepherd hip dysplasia symptoms · dog osteoarthritis treatment · genetic factors in dog hip problems
Abstract
AbstractBackgroundHip dysplasia and osteoarthritis continue to be prevalent problems in veterinary and human medicine. Canine hip dysplasia is particularly problematic as it massively affects several large-sized breeds and can cause a severe impairment of the quality of life. In Finland, the complex condition is categorized to five classes from normal to severe dysplasia, but the categorization includes several sub-traits: congruity of the joint, Norberg angle, subluxation degree of the joint, shape and depth of the acetabulum, and osteoarthritis. Hip dysplasia and osteoarthritis have been proposed to have separate genetic etiologies.ResultsUsing Fédération Cynologique Internationale -standardized ventrodorsal radiographs, German shepherds were rigorously phenotyped for osteoarthritis, and for joint incongruity by Norberg angle and femoral head center position in relation to dorsal acetabular edge. The affected dogs were categorized into mild, moderate and severe dysplastic phenotypes using official hip scores. Three different genome-wide significant loci were uncovered. The strongest candidate genes for hip joint incongruity were noggin (NOG), a bone and joint developmental gene on chromosome 9, and nanos C2HC-type zinc finger 1 (NANOS1), a regulator of matrix metalloproteinase 14 (MMP14) on chromosome 28. Osteoarthritis mapped to a long intergenic region on chromosome 1, between genes encoding for NADPH oxidase 3 (NOX3), an intriguing candidate for articular cartilage degradation, and AT-rich interactive domain 1B (ARID1B) that has been previously linked to joint laxity.ConclusionsOur findings highlight the complexity of canine hip dysplasia phenotypes. In particular, the results of this study point to the potential involvement of specific and partially distinct loci and genes or pathways in the development of incongruity, mild dysplasia, moderate-to-severe dysplasia and osteoarthritis of canine hip joints. Further studies should unravel the unique and common mechanisms for the various sub-traits.
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Search related cases →Original publication on Crossref: https://doi.org/10.1186/s12864-019-6422-6