Peer-reviewed veterinary case report
Genetic risk factors for late-onset Alzheimer's disease drive senescence in female tauopathy mice.
- Journal:
- Neuron
- Year:
- 2024
- Authors:
- Hensley-McBain, Tiffany & Orr, Miranda E
- Affiliation:
- McLaughlin Research Institute · United States
- Species:
- rodent
Abstract
Carling et al. report that late-onset Alzheimer's disease (LOAD) risk alleles drive cellular senescence, a hallmark of aging, in a tau- and sex-dependent manner. Mechanistic insights into interactions among genetic risk, biological aging, and sex differences in LOAD are presented.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39637835/