Peer-reviewed veterinary case report
Genetic signatures for a rodent model of Parkinson's disease using combinatorial optimization methods.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2008
- Authors:
- Hourani, Mou'ath et al.
- Affiliation:
- School of Electrical Engineering and Computer Science · United Kingdom
Abstract
This chapter illustrates the use of the combinatorial optimization models presented in Chapter 19 for the Feature Set selection and Gene Ordering problems to find genetic signatures for diseases using micro-array data. We demonstrate the quality of this approach by using a microarray dataset from a mouse model of Parkinson's disease. The results are accompanied by a description of the currently known molecular functions and biological processes of the genes in the signatures.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18712315/