Peer-reviewed veterinary case report
Genetics of Immune Disease in the Horse.
- Journal:
- The Veterinary clinics of North America. Equine practice
- Year:
- 2020
- Authors:
- Tallmadge, Rebecca L et al.
- Affiliation:
- College of Veterinary Medicine · United States
- Species:
- horse
Abstract
Host defenses against infection by viruses, bacteria, fungi, and parasites are critical to survival. It has been estimated that upwards of 7% of the coding genes of mammals function in immunity and inflammation. This high level of genomic investment in defense has resulted in an immune system characterized by extraordinary complexity and many levels of redundancy. Because so many genes are involved with immunity, there are many opportunities for mutations to arise that have negative effects. However, redundancy in the mammalian defense system and the adaptive nature of key immune mechanisms buffer the untoward outcomes of many such deleterious mutations.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32654783/