Peer-reviewed veterinary case report
Genetic risk factors for chronic eye inflammation in Australian
By Karamatic, Steven et al.·Published in Genes·2022·Greyhound Racing Victoria, Australia·View original on PubMed →
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Original publication title: Genome-Wide Association Analysis for Chronic Superficial Keratitis in the Australian Racing Greyhound.
- Species:
- dog
Plain-English summary
A group of Australian Racing Greyhounds was studied to understand chronic superficial keratitis (CSK), an eye condition that can lead to discomfort and blindness. The research found specific genetic markers linked to CSK, suggesting that some greyhounds are more at risk due to their genetics and exposure to sunlight. The study identified three significant genetic variants that may help in developing genetic tests for breeding healthier dogs. While the findings are promising, further research is needed to confirm these markers before they can be used in breeding programs.
People also search for: greyhound eye problems · chronic superficial keratitis treatment · dog eye condition genetics
Abstract
Chronic superficial keratitis (CSK) is a progressive inflammatory condition of the eye (cornea) that can cause discomfort and blindness. Differential disease risk across dog breeds strongly suggests that CSK has a genetic basis. In addition to genetic risk, the occurrence of CSK is exacerbated by exposure to ultraviolet light. Genome-wide association analysis considered 109 greyhounds, 70 with CSK and the remainder with normal phenotype at an age over four years. Three co-located variants on CFA18 near the 5' region of the Epidermal Growth Factor Receptor () gene were associated with genome-wide significance after multiple-test correction (BICF2P579527, CFA18: 6,068,508, p= 1.77 × 10, p= 0.017; BICF2P1310662, CFA18: 6,077,388, p= 4.09 × 10, p= 0.040; BICF2P160719, CFA18: 6,087,347, p= 4.09 × 10, p= 0.040) (canFam4)). Of the top 10 associated markers, eight were co-located with the significantly associated markers on CFA18. The associated haplotype on CFA18 is protective for the CSK condition.is known to play a role in corneal healing, where it initiates differentiation and proliferation of epithelial cells that in turn signal the involvement of stromal keratocytes to commence apoptosis. Further validation of the putative functional variants is required prior to their use in genetic testing for breeding programs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35893065/