Peer-reviewed veterinary case report
Genes linked to cruciate ligament rupture in Newfoundland dogs
By Baird, A E G et al.·Published in Animal genetics·2014·Department of Infection Biology, United Kingdom·View original on PubMed →
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Original publication title: Genome-wide association study identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs.
- Species:
- dog
Plain-English summary
A group of Newfoundland dogs was studied to understand why some of them develop cranial cruciate ligament rupture (CCLR), a common cause of limping in dogs. Researchers found specific genetic markers linked to this condition, particularly in two genes that may relate to nerve pathways. This information could help identify dogs at risk for CCLR and guide future breeding practices to reduce the occurrence of this painful injury.
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Abstract
Cranial cruciate ligament rupture (CCLR) is the most common cause of pelvic limb lameness in dogs. To investigate the genetic basis of canine CCLR, we conducted a genome-wide association study using a canine SNP array in Newfoundland pedigree dogs with and without CCLR (n = 96). We identified three main chromosomal regions of CCLR association (on chromosomes 1, 3 and 33). Each of these regions was confirmed by Sequenom genotyping in a further cohort of Newfoundlands (n = 271). The results, particularly SNPs identified in the SORCS2 and SEMA5B genes, suggest that there may be neurological pathways involved in susceptibility to canine CCLR.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24835129/