Peer-reviewed veterinary case report
Genome-wide identification of murine interferon genes in microglial-mediated neuroinflammation in Alzheimer's disease.
- Journal:
- Journal of neuroimmunology
- Year:
- 2023
- Authors:
- Shippy, Daniel C & Ulland, Tyler K
- Affiliation:
- Department of Pathology and Laboratory Medicine · United States
- Species:
- rodent
Abstract
Interferons play a major role in microglial-mediated neuroinflammation in Alzheimer's disease (AD). We investigated the interferon transcriptome (AD versus non-AD) using N9 and murine microglia. We identified 64 interferon-related differentially expressed genes (DEG) in LPS-stimulated N9 microglia versus control cells, 26 DEG in microglia from 5XFAD versus wild-type mice, with 13 DEG common to both datasets. Network analyses identified potential key mediators (Cxcl10, Ifit3) of the interferon response in AD. Gene-drug interaction analysis identified therapeutics targeting interferon-related genes. These data characterize the microglial interferon response in AD, providing new targets and therapeutics directed towards interferon-related neuroinflammation in AD.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/36708632/