Peer-reviewed veterinary case report
New pneumovirus found in dogs with sudden breathing illness
By Renshaw, Randall et al.·Published in Veterinary microbiology·2011·Department of Population Medicine and Diagnostic Sciences, United States·View original on PubMed →
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Original publication title: Genomic analysis of a pneumovirus isolated from dogs with acute respiratory disease.
- Species:
- dog
Plain-English summary
A group of dogs in two related shelters developed breathing problems due to a newly discovered virus called canine pneumovirus (CnPnV). This virus was found in several dogs across different locations in the USA, suggesting it is spreading. The researchers identified unique genetic features of this virus compared to similar viruses in mice. While the study focused on the virus's genetic makeup, it highlights the importance of monitoring respiratory illnesses in dogs, especially in shelter settings. Further research is needed to understand how to treat and prevent infections caused by this virus.
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Abstract
A previously unrecognized virus belonging to the subfamily Pneumovirinae and most closely related to murine pneumovirus (MPV) was identified in domestic dogs in 2 related animal shelters. Additional diagnostic testing yielded 3 new viral isolates and identified 6 additional PCR positive dogs from other USA locations indicating that its distribution is not geographically limited. Nucleotide sequences encompassing 9 of the 10 genes were compared to the only 2 available MPV strains, 15 and J3666. Several features distinguished the canine pneumovirus (CnPnV) from the murine strains. Two regions of diversity were identified in the amino-proximal region of P and the overlapping P2 ORF was only 54 amino acids (aa) compared to 137aa in MPV. The G protein had an amino-terminal cytoplasmic tail 18aa longer than in the MPV strains. The CnPnV SH protein showed the highest divergence with only 90.2% aa identity when compared to MPV strain 15. Like strain 15, the CnPnV SH ORF coded for a protein of 92aa while J3666 has a 114aa variant. Comparison of CnPnV isolates at culture passages 4 and 17 revealed 7nt differences within the 8598nt sequenced. Of note was a substitution at nt 364 in G resulting in a termination codon that would produce a truncated G protein of 122aa. Analysis of early passage and ex vivo samples showed the termination codon in G to be predominant after 6 days in culture indicating rapid selection of the mutation in A72 cells.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21324612/