Peer-reviewed veterinary case report
Genomic and proteomic analysis of mammary tumors arising in transgenic mice.
- Journal:
- Journal of proteome research
- Year:
- 2005
- Authors:
- Xie, Lu et al.
- Affiliation:
- Department of Cancer Biology · United States
- Species:
- rodent
Abstract
Transforming growth factor-beta (TGF-beta) is the prototype of a large family of signaling molecules. TGF-beta signaling profoundly influences tumor development as demonstrated in several engineered mouse models. The present study was designed to identify differences by cDNA microarray and MALDI-TOF MS analyses in mammary carcinomas with and without TGF-beta signaling. The results demonstrate a significant potential for combination of profiling technologies to further understand the molecular mechanisms of breast cancer.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16335954/