Peer-reviewed veterinary case report
Deadly dog circovirus outbreak in South America studied
By Kotsias, Fiorella et al.·Published in PloS one·2019·Cá·View original on PubMed →
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Original publication title: Genomic characterization of canine circovirus associated with fatal disease in dogs in South America.
- Species:
- dog
Plain-English summary
A group of dogs in Argentina suffered from severe gastroenteritis (inflammation of the stomach and intestines) that led to fatalities. Researchers found that these dogs were infected with canine circovirus (CanineCV) along with canine parvovirus (CPV), which is known to cause similar symptoms. While the exact role of CanineCV in causing illness is still being studied, this outbreak marks the first time it has been linked to serious disease in dogs in South America. Understanding this virus could help veterinarians better diagnose and treat affected dogs in the future.
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Abstract
Canine circovirus (CanineCV) was detected, together with canine parvovirus (CPV), in samples from an outbreak of fatal gastroenteritis in dogs in Argentina. We obtained the full-length genome of this recently discovered virus by overlapping PCR, designated strain UBA-Baires. Sequence analysis revealed a highly conserved genome but also showed several unique mutations in amino acids from the capsid protein that have not been previously reported. Phylogenetic analysis shows that this strain is more closely related to European strains than to viruses detected in North America or Asia. Although the pathogenic role of CanineCV in dogs is still unclear, this study highlights the importance of CanineCV as a coinfecting virus in disease development. To our knowledge, this is the first report of the involvement of CanineCV in severe clinical disease in dogs in South America. Our results expand our information on the geographical extent of this virus and contribute to the understanding of its role in disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31237902/