Genomic Sequencing and Analysis of New Variants of Enzootic Nasal Tumour Virus Type 2 Revealed Recombination Events between Different Sublineages.

Abstract

In recent years, multiple regions in China have experienced an increase in the occurrence of enzootic nasal tumour virus type 2 (ENTV-2) infections. This research highlights the initial full genomic sequence of ENTV-2 isolated from Guizhou, a province in southwest China. The newly identified strain GZZY1, which belongs to the ENTV-2, had its complete genome analysed and found to be 7504 base pairs in length. Based on a phylogenetic analysis, GZZY1 has been classified as part of the potential sublineage 1.6. Additionally, recombination analysis indicates that GZZY1 may be a recombinant strain, with the gag and env genes serving as the recombination sites, likely originating from sublineages 1.5 and 1.2. In conclusion, this study presents the genomic analysis of GZZY1, a novel ENTV-2 strain isolated from the Guizhou region of China, providing new information about the evolutionary structure and recombination potential of the virus in China. Our findings provide insights into the genetic makeup and potential variations of ENTV-2 in China, which could enhance our understanding of its evolutionary patterns.