Peer-reviewed veterinary case report
Fatal coronavirus infection causing intestinal disease in US puppies
By Licitra, Beth N et al.·Published in Journal of clinical microbiology·2014·Department of Microbiology and Immunology, United States·View original on PubMed →
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Original publication title: Genotypic characterization of canine coronaviruses associated with fatal canine neonatal enteritis in the United States.
- Species:
- dog
Plain-English summary
Eleven puppies from various locations in the United States were diagnosed with severe intestinal issues caused by a type of canine coronavirus (CCoV). Symptoms included severe enteritis, and some puppies also had complications like intussusception (a condition where part of the intestine folds into itself). Testing showed that CCoV was present in the intestines of all the puppies, and some had additional infections with parvovirus or bacteria. This study highlights the importance of recognizing CCoV as a potential cause of serious gastrointestinal problems in young puppies, especially those in crowded environments.
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Abstract
Emerging canine coronavirus (CCoV) variants that are associated with systemic infections have been reported in the European Union; however, CCoV-associated disease in the United States is incompletely characterized. The purpose of this study was to correlate the clinicopathological findings and viral antigen distribution with the genotypic characteristics of CCoV in 11 puppies from nine premises in five states that were submitted for diagnostic investigation at Cornell University between 2008 and 2013. CCoV antigen was found in epithelial cells of small intestinal villi in all puppies and the colon in 2 of the 10 puppies where colon specimens were available. No evidence of systemic CCoV infection was found. Comparative sequence analyses of viral RNA extracted from intestinal tissues revealed CCoV-II genotype in 9 out of 11 puppies. Of the nine CCoV-IIs, five were subtyped as group IIa and one as IIb, while three CCoVs could not be subtyped. One of the CCoV-IIa variants was isolated in cell culture. Infection with CCoV alone was found in five puppies, of which two also had small intestinal intussusception. Concurrent infections with either parvovirus (n = 1), attaching-effacing Escherichia coli (n = 4), or protozoan parasites (n = 3) were found in the other six puppies. CCoV is an important differential diagnosis in outbreaks of severe enterocolitis among puppies between 4 days and 21 weeks of age that are housed at high population density. These findings will assist with the rapid laboratory diagnosis of enteritis in puppies and highlight the need for continued surveillance for CCoV variants and intestinal viral diseases of global significance.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25253797/