Peer-reviewed veterinary case report
Genetic test for exercise collapse in Labrador retrievers
By Takanosu, Masamine et al.·Published in Veterinary journal (London, England : 1997)·2012·Nasunogahara Animal Clinic, Japan·View original on PubMed →
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Original publication title: Genotyping of exercise-induced collapse in Labrador retrievers using an allele-specific PCR.
- Species:
- dog
Plain-English summary
A group of 133 Labrador retrievers in Japan was tested for exercise-induced collapse (EIC), a genetic condition that can cause dogs to suddenly collapse after intense exercise. Out of these dogs, 6 were found to have the condition, while 50 were carriers of the gene mutation that causes EIC. This study developed a specific test to identify the mutation responsible for this disorder, which can help breeders and owners understand the risk of EIC in their dogs. Knowing whether a dog is a carrier or affected can guide owners in managing their pet's exercise routine to prevent episodes of collapse.
People also search for: Labrador retriever exercise-induced collapse · EIC testing for dogs · symptoms of exercise-induced collapse in dogs
Abstract
Exercise-induced collapse (EIC) is an autosomal recessive disorder in Labrador retrievers. In this study, an allele-specific PCR was developed to detect the point mutation G767T in exon 6 of canine DNM1, previously shown to be responsible for canine EIC. Of 133 Labrador retrievers tested in Japan, 6 (4.5%) were homozygous (EIC) and 50 (37.6%) were heterozygous (carriers) for the G767T mutation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22104507/