Peer-reviewed veterinary case report
Genotyping Protocol for the Alpha-1 Antitrypsin (PiZ) Mouse Model.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2017
- Authors:
- Gruntman, Alisha M
- Affiliation:
- University of Massachusetts Medical School · United States
- Species:
- rodent
Abstract
The most common alpha-1 antitrypsin (AAT) mutant variant is a missense mutation (E342K), commonly referred to as PiZ. A transgenic mouse model exists that expresses the mutant human PiZ AAT gene. This protocol outlines the procedure used to extract DNA from and genotype AAT transgenic (PiZ) mice.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28752446/