Peer-reviewed veterinary case report
Geographical sequence variation in the Leishmania major virulence factor P46.
- Journal:
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
- Year:
- 2015
- Authors:
- Bifeld, Eugenia et al.
- Affiliation:
- Bernhard Nocht Institute for Tropical Medicine · Germany
- Species:
- rodent
Abstract
Cutaneous leishmaniasis as caused by Leishmania major is a zoonotic infection with wide epidemiological impact. The L. major P46 virulence gene was shown to boost the parasite's virulence and extends its range of experimental hosts. Here we show that P46 is subject to significant geographical sequence variations that may reflect the adaption to different reservoir hosts. This view is supported by the results of passage experiments using P46 variants in different experimental hosts. Conversely, loss of P46 expression leads to attenuation both in vitro and in BALB/c mice. Although part of the L. major exosomal protein payload, P46 is not required for exosome-mediated immune modulation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25558028/