Peer-reviewed veterinary case report
Germ-Free Mice Model for Studying Host-Microbial Interactions.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2016
- Authors:
- Bhattarai, Yogesh & Kashyap, Purna C
- Affiliation:
- Department of Gastroenterology and Hepatology · United States
- Species:
- rodent
Abstract
Germ-free (GF) mice are a relevant model system to study host-microbial interactions in health and disease. In this chapter, we underscore the importance of using GF mice model to study host-microbial interactions in obesity, immune development and gastrointestinal physiology by reviewing current literature. Furthermore, we also provide a brief protocol on how to setup a gnotobiotic facility in order to properly maintain and assess GF status in mice colonies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27150088/