Peer-reviewed veterinary case report
Gestational bisphenol-A exposure lowers the threshold for autoimmunity in a model of multiple sclerosis.
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Year:
- 2017
- Authors:
- Rogers, James A et al.
- Affiliation:
- Hotchkiss Brain Institute and the Department of Clinical Neurosciences · Canada
- Species:
- rodent
Abstract
Environmental and hormonal factors are implicated in dysimmunity in multiple sclerosis. We investigated whether bisphenol-A, a prominent contaminant with endocrine-disrupting capabilities, altered susceptibility in an inflammatory model of multiple sclerosis. We found that gestational, but not adult, exposure to bisphenol-A increased the development of experimental autoimmune encephalomyelitis in adulthood in male, but not female, mice when a suboptimal disease-inducing immunization was used. Gestational bisphenol-A in male mice primed macrophages in adulthood and raised granulocyte-colony stimulating factor and neutrophil counts/activity postsuboptimal immunization. Neutralizing granulocyte-colony stimulating factor blocked susceptibility to disease in bisphenol-A mice. Early life exposure to bisphenol-A may represent an environmental consideration in multiple sclerosis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28439012/