Peer-reviewed veterinary case report
Glial scar-modulation as therapeutic tool in spinal cord injury in animal models.
- Journal:
- Acta cirurgica brasileira
- Year:
- 2017
- Authors:
- Orlandin, Jéssica Rodrigues et al.
- Affiliation:
- Veterinary Medicine Department · Brazil
Plain-English summary
Spinal cord injuries in pets can lead to serious problems, including permanent disability or even the need for euthanasia. When an injury occurs, inflammation can create a glial scar, which helps protect healthy nerve pathways but also makes it harder for the body to heal and regenerate nerves. Recent research has explored new treatments, including cell therapy and certain medications that can help reduce this scar and improve recovery. These innovative approaches show promise in helping pets regain movement after a spinal cord injury. Overall, the treatments appear to be effective in promoting better mobility in affected animals.
Abstract
PURPOSE: Spinal Cord injury represents, in veterinary medicine, most of the neurological attendances and may result in permanent disability, death or euthanasia. Due to inflammation resulting from trauma, it originates the glial scar, which is a cell interaction complex system. Its function is to preserve the healthy circuits, however, it creates a physical and molecular barrier that prevents cell migration and restricts the neuroregeneration ability. METHODS: This review aims to present innovations in the scene of treatment of spinal cord injury, approaching cell therapy, administration of enzyme, anti-inflammatory, and other active principles capable of modulating the inflammatory response, resulting in glial scar reduction and subsequent functional improvement of animals. RESULTS: Some innovative therapies as cell therapy, administration of enzymes, immunosuppressant or other drugs cause the modulation of inflammatory response proved to be a promising tool for the reduction of gliosis. CONCLUSION: Those tools promise to reduce gliosis and promote locomotor recovery in animals with spinal cord injury.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28300871/