Peer-reviewed veterinary case report
Dog with glucagon tumor causing skin sores and low amino acids
By Allenspach, K et al.·Published in The Journal of small animal practice·2000·Department of Internal Medicine·View original on PubMed →
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Original publication title: Glucagon-producing neuroendocrine tumour associated with hypoaminoacidaemia and skin lesions.
- Species:
- dog
Plain-English summary
A 9-year-old neutered female Bernese mountain dog was brought in with skin lesions and diagnosed with a glucagon-producing tumor, which is a type of cancer. Blood tests showed high levels of glucagon and low levels of amino acids, indicating serious health issues. Unfortunately, the dog's condition worsened, and she was euthanized. A necropsy revealed that the cancer had spread to her liver.
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Abstract
A nine-year-old neutered female crossbred Bernese mountain dog was diagnosed with superficial necrolytic dermatitis and a glucagon-producing islet cell tumour. Laboratory findings included hyperglucagonaemia and hypoaminoacidaemia. The dog was euthanased because of progression of the disease, and necropsy revealed liver metastases of a neuroendocrine carcinoma with immunohistochemical expression of glucagon and somatostatin. This report represents a case of canine glucagonoma syndrome; the previously reported cases in dogs are also briefly described.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11023126/