Peer-reviewed veterinary case report
Glucocorticoid hormone changes in critically ill septic dogs
By Boag, A M et al.·Published in Domestic animal endocrinology·2020·Hospital for Small Animals, United Kingdom·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Glucocorticoid metabolism in critically ill dogs (Canis lupus familiaris).
- Species:
- dog
Plain-English summary
A critically ill dog with sepsis was studied to understand how its body processed stress hormones like cortisol. The research found that dogs in septic shock had higher levels of cortisol, and those with increased bound cortisol were less likely to survive. Additionally, the study showed that the dogs had lower activity of an enzyme that helps convert cortisol to cortisone, which is important for managing stress. This suggests that the way dogs handle stress hormones during severe illness is different from humans. Unfortunately, some dogs did not survive despite these findings, highlighting the seriousness of sepsis in pets.
People also search for: dog sepsis treatment · high cortisol levels in dogs · critically ill dog care
Abstract
Critical illness due to sepsis is a major global health concern associated with a high burden of mortality and cost. Glucocorticoid dysregulation in human sepsis is associated with poorer outcomes. This study examines glucocorticoid metabolism in septic canine patients to delineate elements of cellular dysregulation in common with critically ill humans and explore potential differences. This was a prospective case-control study conducted in the veterinary specialist critical care departments of two University teaching hospitals. Critically ill canine patients with naturally occurring sepsis or septic shock were compared with an in-hospital control population. Serum total, bound, and free cortisol concentrations were increased in septic shock (P < 0.001), and higher bound cortisol was associated with nonsurvival (P = 0.026). Urinary Gas Chromatography-Tandem Mass Spectrometry was performed to assess urinary glucocorticoid metabolites and estimate intracellular glucocorticoid metabolism. Decreased renal 11β-hydroxysteroid dehydrogenase 2 (11βHSD2) activity inferred from increased urinary cortisol-to-cortisone ratio was observed in critically ill dogs (P < 0.001). Decreased 11βHSD2 activity (P = 0.019) and increased A-ring reduction of cortisone (P = 0.001) were associated with nonsurvival within the critically ill dogs. Intriguingly, two dogs were identified with low circulating total cortisol (<2 mg/dL) associated with increased A-ring reduction of cortisol, not previously described. Investigation of spontaneous canine sepsis and septic shock reveals dysregulation of cortisol to cortisone conversion similar to that observed in human patients, but with differences in A-ring reduction compared with those reported in humans. In addition, two dogs with high levels of cortisol inactivation associated with low circulating cortisol concentrations were identified.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32169755/