Peer-reviewed veterinary case report
Glutamate release and uptake processes are altered in a new mouse model of amyotrophic lateral sclerosis.
- Journal:
- Doklady. Biochemistry and biophysics
- Year:
- 2016
- Authors:
- Grigoriev, V V et al.
- Affiliation:
- Institute of Physiologically Active Compounds
- Species:
- rodent
Abstract
In this paper, we showed that in the cortex of mice expressing an abberant form of FUS protein that model amyotrophic lateral sclerosis (ALS), the processes of KCl-induced and basal [(3)H]glutamate release and uptake are altered at the presymptomatic stage as compared to the non-transgenic littermates. The change in these three parameters in transgenic animals causes excitotoxicity, which, in turn, may lead to massive loss of motor neurons and the onset of ALS symptoms.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27417710/