Peer-reviewed veterinary case report
Mixed-breed dog with fatal progressive neurological disease Sandhoff
By Kohyama, Moeko et al.·Published in Journal of the American Animal Hospital Association·2015·and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: GM2 Gangliosidosis Variant 0 (Sandhoff Disease) in a Mixed-Breed Dog.
- Species:
- dog
Plain-English summary
A 10-month-old male mixed-breed dog started showing signs of neurological problems, including difficulty walking, trouble with balance, and vision issues. Unfortunately, the condition worsened over time, and the dog passed away at 21 months old. The vet diagnosed him with GM2 gangliosidosis variant 0, also known as Sandhoff disease, through specific tests. This case is significant as it's the first reported instance of this rare disease in a mixed-breed dog.
People also search for: dog ataxia symptoms · mixed-breed dog vision problems · Sandhoff disease in dogs · puppy neurological issues · dog progressive disease treatment
Abstract
GM2 gangliosidosis variant 0 (Sandhoff disease, SD) is a fatal, progressive, neurodegenerative lysosomal storage disease caused by simultaneous deficiencies of acid β-hexosaminidases A and B. Canine SD has so far been identified only in two purebreeds. In this article, we present the case of a 10 mo old, male dog of mixed breed that developed progressive neurological signs including ataxia, postural deficit, and visual deficits and finally died at the age of 21 mo. The dog was diagnosed with SD on the basis of the results of biochemical and histopathological analyses. This is the third report of canine SD and the first time it has been identified in a mixed breed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26535459/