Peer-reviewed veterinary case report
Granular cell tumor found on left vocal cord of dog
By Rossi, G et al.·Published in Journal of comparative pathology·2007·Department of Animal Science, Italy·View original on PubMed →
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Original publication title: Granular cell tumour affecting the left vocal cord in a dog.
- Species:
- dog
Plain-English summary
A 6-year-old male dog was found to have a growth on his left vocal cord, which caused swelling in his throat and enlargement of the tonsil on that side. The growth was identified as a granular cell tumor, a rare type of tumor that can occur in vocal cords. The diagnosis was confirmed through various tests, including a look at the cells under a microscope. While the abstract does not mention treatment or outcome, granular cell tumors can sometimes be surgically removed, which may help alleviate symptoms.
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Abstract
Granular cell tumours (GCTs) have been described in human vocal cords, but not in those of the dog. A single polyp in the left vocal cord, associated with laryngeal oedema and monolateral hyperplasia of the tonsil, was observed endoscopically in a 6-year-old male dog. Cytologically, the mass was characterized by well-defined polygonal cells, with granular cytoplasm and an eccentric nucleus. Histologically, the mass showed sheets of globoid to polygonal cells, filled with numerous diastase-resistant, periodic acid-Schiff-positive granules, and scanty stroma. Ultrastructurally, the granules were represented by heterogeneous lysosomes of variable size, suggesting a diagnosis of GCT. As reported in man, hyperplasia of the laryngeal and tonsillar epithelium and the presence of foci of pearl-like epithelial cells, mimicking invasive squamous cell carcinoma, were observed. Immunohistochemical examination revealed labelling of neoplastic cells for S-100 protein, CD68, collagen IV, and, focally, for glial fibrillary acidic protein, neuron-specific enolase and vimentin. These findings suggested a Schwann cell origin of the GCT.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17258228/