Peer-reviewed veterinary case report
Beagle dog with cerebellar granule cell loss causing hypoplasia
By Tago, Y et al.Ā·Published in Laboratory animalsĀ·1993Ā·Mitsubishi Kasei Institute of Toxicological and Environmental Sciences, JapanĀ·View original on PubMed ā
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Original publication title: Granule cell type cerebellar hypoplasia in a beagle dog.
- Species:
- dog
Plain-English summary
A 19-month-old male beagle was found to have cerebellar hypoplasia, a condition where the cerebellum (the part of the brain that controls movement) is underdeveloped, leading to issues with coordination and balance. In this case, there was a significant loss of granule cells, which are important for proper brain function, while other cells remained mostly normal. Unfortunately, the study did not provide information on treatment or recovery outcomes for this dog.
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Abstract
Cerebellar hypoplasia characterized by severe depletion of granule cells and almost intact Purkinje cells was found in a male 19-month-old beagle dog used in a toxicity study. Microscopically, there was a narrow space lacking granule cells between the row of Purkinje cells and the medulla. Gliosis was not seen in any portion of the cerebellum including this space. No significant changes were seen in the Purkinje cells except for occasional cytoplasmic vacuolation. In the molecular layer and medulla, no histopathological abnormalities were observed.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8501896/