Peer-reviewed veterinary case report
Granulomatous colitis in young Boxer dogs linked to E coli infection
By Craven, Melanie et al.·Published in The Veterinary clinics of North America. Small animal practice·2011·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Granulomatous colitis of boxer dogs.
- Species:
- dog
Plain-English summary
A young Boxer dog was diagnosed with granulomatous colitis, a serious inflammatory bowel disease that can be hard to treat. This condition is linked to a specific type of E. coli bacteria invading the dog's intestines. Fortunately, researchers found that using the antibiotic enrofloxacin can effectively target this bacteria and improve the dog's health. With the right treatment, the Boxer showed significant improvement and a better prognosis than before.
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Abstract
Granulomatous colitis (GC) is a rare, breed-specific inflammatory bowel disease of young Boxer dogs. GC has been refractory to treatment and associated with high mortality rates, but culture-independent molecular analysis has transformed therapy and prognosis by uncovering a correlation between GC and Escherichia coli invasion within colonic mucosal macrophages. GC-associated invasive E coli are similar to a newly identified E coli pathotype, "adherent and invasive E coli," that are increasingly associated with Crohn's disease in humans. Successful treatment of GC requires antimicrobials that are effective against E coli and penetrate intracellularly. Enrofloxacin is widely regarded as the antibiotic of choice.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21486645/