Peer-reviewed veterinary case report
Dog with rare scarring hair loss treated with ciclosporin
By Panzuti, Pauline et al.·Published in Veterinary dermatology·2020·VetAgro Sup, France·View original on PubMed →
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Original publication title: Granulomatous mural folliculitis in a dog treated with ciclosporin and methotrexate.
- Species:
- dog
Plain-English summary
A 13-year-old spayed female Pyrenean shepherd was brought in for hair loss and scarring on her skin that had been worsening for a month. After testing, the vet diagnosed her with a rare skin condition called granulomatous mural folliculitis. The dog was treated with two medications, ciclosporin and methotrexate, which helped stabilize her skin condition. After treatment, her skin disease remained stable for six months, showing that these medications can be effective for this type of skin problem in dogs.
People also search for: dog hair loss treatment · Pyrenean shepherd skin problems · ciclosporin for dogs · methotrexate for dog skin disease
Abstract
BACKGROUND: Canine granulomatous mural folliculitis is a very rare cause of scarring alopecia with unknown pathogenesis. HYPOTHESIS/OBJECTIVES: To report a case of granulomatous mural folliculitis in a dog treated with ciclosporin (Cs) and methotrexate (MTX). ANIMAL: A 13-year-old spayed female Pyrenean shepherd dog with a one month history of scarring alopecia. METHODS AND RESULTS: Histopathological examination revealed a granulomatous and lymphocytic mural and necrotizing folliculitis and furunculosis. Immunochemistry, using antibodies for CD3, CD204, CD206, IBA-1 and CD208, revealed that CD3lymphocytes were infiltrating the outer root sheath along with IBA-1or CD204cells. Ciclosporin (5 mg/kg once daily) and MTX (0.25 mg/kg once weekly then 0.5 mg/kg once weekly) were initiated simultaneously, and Cs was stopped after stabilization of the lesions. The dog's skin disease was stable for six months. CONCLUSIONS AND CLINICAL IMPORTANCE: To the best of the authors' knowledge, this is the first report of the long-term management of a granulomatous mural folliculitis in a dog. Ciclosporin and MTX appeared to be an effective treatment option. Additional treated cases are needed to assess the effectiveness of MTX in canine immune-mediated diseases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31908101/