Peer-reviewed veterinary case report
Granulomatous typhlocolitis, lymphangitis, and lymphadenitis in a horse infected with Listeria monocytogenes, Salmonella Typhimurium, and cyathostomes.
- Journal:
- Veterinary pathology
- Year:
- 2013
- Authors:
- Nemeth, N M et al.
- Affiliation:
- Department of Pathology · United States
- Species:
- horse
Plain-English summary
A 15-year-old American Quarter horse mare was put to sleep because she wasn't getting better from severe diarrhea. When examined, her large intestines showed thickened walls and nodules, and the nearby lymph nodes were also enlarged. Tests revealed she had a serious inflammation of the intestines and lymph vessels, along with a bacterial infection from Listeria monocytogenes, which is uncommon in horses, and a concurrent infection with Salmonella. The combination of these infections likely played a role in her condition. Unfortunately, the treatment did not work, leading to her euthanasia.
Abstract
A 15-year-old American Quarter horse mare was euthanized because of poor response to therapy for severe diarrhea. Significant gross findings were limited to the large intestines. The walls of the cecum and colon were thickened with widely scattered nodules in the mucosa and submucosa that extended into the enlarged colic lymph nodes. Microscopically, there was severe granulomatous typhlocolitis, lymphangitis, and lymphadenitis, with many intralesional Gram-positive, non-acid-fast coccobacilli and few cyathostomes. Intralesional bacteria were immunohistochemically and polymerase chain reaction (PCR) assay positive for Listeria monocytogenes. Concurrent infection with Salmonella enterica serovar Typhimurium was detected by PCR and culture. Infection with L. monocytogenes in horses is rare, and coinfection with Salmonella and small strongyles probably contributed to the development of granulomatous typhlocolitis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22688587/