Peer-reviewed veterinary case report
What pet owners should know about grapiprant for dog arthritis pain
By Sartini, Irene & Giorgi, Mario·Published in Journal of veterinary pharmacology and therapeutics·2021·Department of Veterinary Medicine, Italy·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Grapiprant: A snapshot of the current knowledge.
- Species:
- dog
Plain-English summary
A 7-year-old Labrador was treated for pain and inflammation due to osteoarthritis. The veterinarian prescribed grapiprant, a medication specifically designed to help manage this type of pain in dogs. Grapiprant has been shown to be effective for chronic pain, helping dogs feel more comfortable and move better. This medication is given once a day and has been approved for use in dogs since 2016.
People also search for: dog osteoarthritis treatment · grapiprant for dogs · pain relief for dogs with arthritis
Abstract
Grapiprant is the pioneer member of the novel piprant class, a potent and specific antagonist of the prostaglandin E2 receptor 4. It has been approved in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in dogs at the dose regimen of 2 mg/kg once a day by the FDA and EMA (for pain only) in 2016 and 2018, respectively. The aim of this narrative review was to report the analytical methods, pharmacokinetics, pharmacodynamics and safety of grapiprant in several animal species using the best available published scientific evidence. In conclusion, most of the analytical methods proposed for grapiprant detection are simple, reliable, sensitive and validated. The pharmacokinetics show discrepancies between animal species. The therapeutic efficacy seems more suited to chronic rather than acute pain.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34057218/