Peer-reviewed veterinary case report
Growth hormone helps heal large bone defects in dogs
By Theyse, L F H et al.·Published in Clinical orthopaedics and related research·2006·Department of Clinical Sciences of Companion Animals, Netherlands·View original on PubMed →
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Original publication title: Growth hormone stimulates bone healing in a critical-sized bone defect model.
- Species:
- dog
Plain-English summary
A study found that giving growth hormone to dogs with significant bone injuries helped their bones heal better. In this case, the dogs had critical-sized bone defects, which are serious injuries that can be hard to heal. The treatment led to increased levels of certain growth factors in their blood, which are important for bone healing. While the growth hormone helped stimulate healing, using it directly at the injury site didn’t provide any extra benefits. Overall, the dogs showed improvement in bone healing after receiving the growth hormone treatment.
People also search for: dog bone healing treatment · growth hormone for dogs · critical-sized bone defect in dogs
Abstract
Growth hormone plays an important role in bone metabolism. Treating bone deficits is a major topic in orthopaedic surgery. Our hypothesis was that local continuous growth hormone administration stimulates bone healing in a canine critical-sized bone defect model. Bone formation in the defects was quantified using densitometric image analysis and histomorphometry. After growth hormone treatment, expression levels of insulin-like growth factors-I and II, and growth hormone receptor were determined in the bone regenerate of the original defects. Circulating plasma concentrations of insulin-like growth factors-I and II, and insulin- like growth factor binding proteins-4, and 6 were measured during treatment. Growth hormone administration resulted in healing of bone defects but without an additional effect of local infusion. Expression of insulin-like growth factor-I in the bone regenerate was lower in the growth hormone-treated dogs, whereas insulin-like growth factor-II and growth hormone receptor expression were not increased. Growth hormone increased circulating insulin-like growth factor-I and growth factor-II plasma concentrations. Continuous infusion of growth hormone stimulated bone healing in a canine critical-sized bone defect model. Local delivery of growth hormone did not additionally enhance bone healing. Increased circulating plasma concentrations of insulin-like growth factors-I and II most likely induced bone formation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16505713/