Peer-reviewed veterinary case report
Severe pneumonia and gene changes in dogs with H3N2 flu
By Kang, Young Myong et al.·Published in Veterinary research·2013·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: H3N2 canine influenza virus causes severe morbidity in dogs with induction of genes related to inflammation and apoptosis.
- Species:
- dog
Plain-English summary
A group of dogs infected with the H3N2 canine influenza virus showed severe respiratory issues, including coughing, fever, and weight loss. This virus spreads easily between dogs and can lead to serious lung problems like pneumonia. Infected dogs had increased levels of genes related to inflammation and cell death in their lungs, which contributed to their illness. Treatment typically involves supportive care, including fluids and medications to manage symptoms, and many dogs recover with appropriate veterinary care.
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Abstract
Dogs are companion animals that live in close proximity with humans. Canine H3N2 influenza virus has been isolated from pet dogs that showed severe respiratory signs and other clinical symptoms such as fever, reduced body weight, and interstitial pneumonia. The canine H3N2 influenza virus can be highly transmissible among dogs via aerosols. When we analyzed global gene expression in the lungs of infected dogs, the genes associated with the immune response and cell death were greatly elevated. Taken together, our results suggest that canine H3N2 influenza virus can be easily transmitted among dogs, and that severe pneumonia in the infected dogs may be partially due to the elevated expression of genes related to inflammation and apoptosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24090140/