Peer-reviewed veterinary case report
Hearing outcome of early postnatal exposure to hypoxia in Sprague-Dawley rats.
- Journal:
- The Journal of laryngology and otology
- Year:
- 2014
- Authors:
- Daniel, S J et al.
- Affiliation:
- Department of Otolaryngology - Head and Neck Surgery · Canada
- Species:
- rodent
Abstract
OBJECTIVE: To determine the effect of experimentally induced hypoxia, in the first 10 days of life, on physiological hearing in a Sprague-Dawley rat model. METHODS: A prospective, controlled animal study was carried out using 22 male rat pups. The rats in the hypoxic group ( = 12) were reared in hypoxia for the first 10 days of life, and subsequently reared in normoxia, while those in the control group ( = 10) were reared in normoxia for the duration of the experiment. Hearing was assessed using auditory brainstem response testing at approximately 72 days of age. RESULTS: The hypoxia group had higher auditory brainstem response thresholds for all frequencies tested (more pronounced at 16 kHz), compared with controls. Wave I-V inter-peak latencies were more prolonged in the hypoxic rats, while both groups had similar wave I latencies. CONCLUSION: Chronic postnatal hypoxia induced permanent hearing loss in this Sprague-Dawley rat model. Prolonged wave I-V inter-peak latencies suggested functional abnormality in the central auditory pathway.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24735907/