Peer-reviewed veterinary case report
Heating cancer stem cells to reduce tumor relapse.
- Journal:
- Breast cancer research : BCR
- Year:
- 2011
- Authors:
- Pelicci, Pier Giuseppe et al.
- Affiliation:
- European Institute of Oncology · Italy
Abstract
Tumour relapse is believed to be caused by rare cancer-cells with stem-cell properties (cancer stem cells) that are intrinsically resistant to available treatments. The identification of novel strategies to increase their sensitivity has major clinical implications. Latest clinical trials have shown a positive antitumoral effect of hyperthermia in combination with chemotherapy or radiotherapy. In a recent paper, the combination of increased temperature at the tumour site, generated by laser treatment of intravenously-injected gold nanoshells, and ionizing radiations enhances radiosensitivity of cancer stem cells and tumor response. At the root of the success of hyperthermia in enhancing radio-sensitization of cancer stem cells is the inhibition of their capacity to repair DNA damage, affecting the survival rate of these cells.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21575278/