Peer-reviewed veterinary case report
Hedgehog signaling helps bladder cancer cells grow in dogs
By Gustafson, T L et al.·Published in Veterinary and comparative oncology·2017·Colorado State University, United States·View original on PubMed →
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Original publication title: Hedgehog signaling is activated in canine transitional cell carcinoma and contributes to cell proliferation and survival.
- Species:
- dog
Plain-English summary
A study found that transitional cell carcinoma (TCC), a common bladder tumor in dogs, has a specific signaling pathway called Hedgehog (HH) that helps the cancer cells grow and survive. Researchers discovered that this pathway is active in TCC cells but not in normal bladder tissue. When they used treatments to block this pathway, the cancer cells grew less, although it didn't significantly increase cell death. This suggests that targeting the HH signaling could be a promising new approach for treating TCC in dogs.
People also search for: dog bladder cancer treatment · transitional cell carcinoma in dogs · canine cancer signaling pathways
Abstract
Transitional cell carcinoma (TCC) is the most commonly diagnosed tumor of the canine urinary system. Hedgehog (HH) signaling represents one possible novel therapeutic target, based on its recently identified central role in human urothelial carcinoma. The purpose of this study was to determine if HH mediators are expressed in canine TCC and the effect of inhibition of this pathway on cell growth and survival. HH pathway mediators were found to be expressed in five canine TCC cell lines. Indian HH was expressed in tumor cells in five canine bladder tumor tissues, but not in normal canine bladder tissue. Inhibition of HH signaling with cyclopamine and GANT61 led to significantly decreased cell proliferation but had a smaller effect on apoptosis. These results support future investigation of inhibitors of HH signaling in the treatment of canine TCC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25864514/