Peer-reviewed veterinary case report
Hematopoietic cell transplantation directly into dystrophic muscle fails to reconstitute satellite cells and myofibers.
- Journal:
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
- Year:
- 2007
- Authors:
- Kuhr, Christian S et al.
- Affiliation:
- and Department of Surgery · United States
- Species:
- dog
Abstract
We sought to determine whether wild-type hematopoietic cell transplantation directly into muscle could restore dystrophin expression in a relevant preclinical canine model of Duchenne muscular dystrophy. In recipients rendered tolerant to their dog leukocyte antigen-matched unaffected littermates through hematopoietic stem cell transplantation, intramuscular injection of donor marrow cells produced no evidence of dystrophin expression, and clonal analysis of satellite cells failed to reveal any donor contribution.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17640591/